If I load up the intake with starting fluid it will run for 20-30 seconds. I've got plenty of fuel pressure I don't think the injectors are working properly. I tried using a noid light and nothing, but I have power at both terminals of 1 injector plug. Need some guidance or better understanding of the optispark system

 

Yes, you will have close to battery voltage on injector if PCM does not turn on injector, as shown by noid light.
I would suggest crank angle sensor or cam sensor is not outputting telling PCM engine is turning over.
Just for grins, jumper in a second battery as there may not be enough power generated from present battery for other circuits to work besides starter motor.

 

what year and model/engine?

 

Do you have spark? Security light on? Any codes?

If you play the percentages, no injector pulse and no codes would be a security issue. Of course it can be a failed PCM or mutable sensor failures or even a wiring issue.

We have had several people come here who have had the security light on for a long time but for some reason now the system won’t start. Fix the security light fix the car.